Born to an American father and Zainichi-Korean mother, Kiko Mizuhara has emerged as one of Japan's most visible style leaders. Mother, actress, model, and Chanel favorite, Mizuhara began modeling in 2003 after winning a competition run by Seventeen Japan. Shen then became an exclusive model for the fashion magazine Vivi.  She regularly appears in Elle Japan, Numero Tokyo, Nylon Japan, Vogue Girl Japan, and Ginza Magazine. In May 2016, she graced the cover of i-D Japan, in which she was hailed the "Future of Japan." She has worked with Uniqlo, Jil Sander Navy, Jill Stuart, Häagen-Dazs, and Huawei.

In addition to her modeling work, Kiko has appeared in numerous films and television programs. A favorite of Karl Lagerfeld, she was featured in short films shot by Chanel. In 2010, she co-starred in Tran Anh Hung's NORWEGIAN WOOD with Kenichi Matsuyama and Rinko Kikuchi. She played the supporting role in Mika Ninagawa's HELTER SKELTER, based on the award-winning comic of the same name by Kyoko Okazaki. Ninagawa later shot Mizuhara for a photo book entitled GIRL, published in 2012. She also starred in TRICK THE MOVIE: LAST STAGE in 2014, ATTACK ON TITAN in 2015, and TORNADO GIRL in 2017.